This paper examines the pervasive phenomenon of witchcraft in Africa, particularly in Sub-Saharan regions, where many Christian populations exhibit lives incongruent with their professed faith, often resorting to syncretic practices amid crises. Drawing on theological, anthropological, and socioeconomic perspectives, it identifies root causes in African Traditional Religion's holistic worldview, which integrates spiritual and physical realms, fostering a utilitarian quest for power through mysticism, spirits, and rituals that Christianity inadequately addresses. The study highlights witchcraft's detrimental effects: socially, it erodes community cohesion, trust, and social capital, leading to exclusion, violence, and gender disparities; economically, it perpetuates poverty by discouraging wealth accumulation, innovation, and productivity in agriculture and trade; spiritually, it manifests as idolatry, clashing with biblical prohibitions and inducing anxiety. Biblical analysis frames witchcraft as detestable to God (e.g., Deuteronomy 18:9-13; Galatians 5:19-21), linking it to curses and destruction (Deuteronomy 30:15-20). Proposing solutions, the paper advocates for the church and faith-based organizations to adopt a holistic mission modeled on Christ's (Isaiah 61:1-3; Luke 4:16-19), involving interdisciplinary collaboration, revised theological education, and development of a theology of spirits to combat syncretism and promote integral human flourishing. Ultimately, it calls for scrutinizing cultural practices against Scripture to achieve transformative gospel impact.
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